Ancestral Use of Mushrooms
Our ancestors have used mushrooms as medicine for thousands of years. The Greek physician Hippocrates classified the amadou mushroom as an anti-inflammatory and for cauterizing wounds. The alchemist Tao Hongjing described several medicinal mushrooms, including ling zhi and zhu ling, in use for many centuries before. First peoples of North America used puffball mushrooms as wound healers.
Recent Scientific Interest
The recent surge in scientific interest in medicinal mushrooms is due to their cultural history of use and modern methods for tissue culture of mycelium and testing of individual constituents. G lucidum has at least 16,000 genes coding for over 200,000 compounds, with 400 being "active constituents". Over 150 novel enzymes have been identified from mushroom species.
Delay in Modern Science
The lag in modern scientific exploration of mushrooms is likely due to their ephemeral nature and the perception that they are dangerous and poorly understood.
Mushrooms and Microbes
The medicinal properties of mushrooms are likely due to their relationship with microbes. Many of the chemicals that fungi produce to survive are also active in humans, and our bodies have evolved to respond to these chemicals through pattern recognition receptors that bind to b-glucans.
Diverse Human Responses
The literature on human response to mushrooms shows a magnitude and diversity of effects greater than those seen with plants. This is likely due to the closer relationship between the animal kingdom and mushrooms.
Exploiting Medicinal Properties
Modern science is exploring the use of mycelium to find a whole new set of active molecules that interface with modern medicine. Cultivating mushrooms to further exploit their medicinal purposes and using solvents other than water is revealing whole new sets of active constituents.
Emerging Scientific Revolution
We are now fully engaged in a rapidly emerging scientific revolution in medicinal mushrooms, with a growing understanding of their role in ecosystems and potential for use in naturopathic medicine.
Lion's Mane (Hericium erinaceus)
Tree Oysters (Pleurotus ostreatus)
Snow Fungus (Tremella fuciformis)
Turkey tail (Trametes versicolor)
Velvet Foot or Enoki (Flammulina velutipes)
Magic Mushrooms (Psilocybe cubensis)
Lion's mane mushrooms, also known as Hericium erinaceus, have been used in traditional medicine for centuries and are gaining popularity for their potential health benefits. They contain a variety of medicinal compounds, including hericystin and erinacines, which have been shown to have anti-inflammatory and antioxidant properties. They also contain beta-glucans, which have been shown to have immune-boosting effects.
One of the most significant benefits of Lion's mane mushrooms is their ability to promote nerve growth factor (NGF). NGF is a protein that helps to support the growth and survival of nerve cells, which can be beneficial for cognitive function and nerve repair. Studies have shown that consuming Lion's mane mushrooms can increase NGF levels in the body, which may help to improve memory, focus, and overall cognitive function.
Lion's mane mushrooms also show promise in helping to reduce symptoms of anxiety and depression. Studies have found that consuming Lion's mane mushrooms daily can lead to reductions in symptoms such as anxiety, depression and fatigue.
Chaga, also known as Inonotus obliquus, are a type of medicinal mushroom that have been used in traditional medicine for centuries.
Chaga's melanin concentration is higher than any other known organism, this is the reason why it is considered as the king of mushrooms. Chaga is also a rich source of polysaccharides, betulin, betulinic acid, and triterpenoids.
These compounds have been known to have anti-inflammatory, antioxidant and immune-boosting properties and help to protect cells from damage caused by free radicals. They also contain compounds called lanostanoids, which have been shown to have anti-tumor effects.
Chaga mushrooms have also been found to have potential benefits for the skin, it has been shown to help with a variety of skin conditions like eczema and psoriasis, due to its anti-inflammatory properties.
Amanita muscaria is a widely recognized mushroom that has been used in traditional healing practices for centuries. Indigenous tribes across Central and South America, Northern Europe, and Siberia have used Amanita Muscaria for its restorative properties for thousands of years. Today, Amanita Muscaria is used as a sleep aid and is considered to have a therapeutic potential. Amanita Muscaria is not considered a drug in North America and has undergone preclinical trials and research leading to the legalization of its extract.
Psilocybin is a naturally occurring psychoactive substance found in certain types of mushrooms. It is a member of the tryptamine family of compounds, which also includes serotonin and other neurotransmitters. When ingested, psilocybin is converted into psilocin, which is believed to be responsible for its psychoactive effects.
Psilocybin is known for its ability to produce altered states of consciousness, including feelings of euphoria, spiritual enlightenment, and altered perceptions of time and space. The intensity and duration of these effects depend on a variety of factors, including the dose, the individual's sensitivity to psilocybin, and the environment in which it is taken.
In addition to its psychoactive properties, psilocybin has also been studied for its potential therapeutic benefits. Some research suggests that it may be useful in treating a variety of mental health conditions, including depression, anxiety, and addiction. However, more research is needed to fully understand the potential therapeutic uses of psilocybin and to determine the appropriate dosages and administration methods.
Overall, psilocybin is a complex and multifaceted substance that has a long history of use in various cultural and spiritual practices. While it has the potential to produce powerful and transformative experiences, it is also important to be aware of the potential risks and to use it responsibly.
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